A human mitochondriopathy caused by AIF mutation
نویسندگان
چکیده
منابع مشابه
Paradoxical Inhibition of Glycolysis by Pioglitazone Opposes the Mitochondriopathy Caused by AIF Deficiency
Mice with the hypomorphic AIF-Harlequin mutation exhibit a highly heterogeneous mitochondriopathy that mostly affects respiratory chain complex I, causing a cerebral pathology that resembles that found in patients with AIF loss-of-function mutations. Here we describe that the antidiabetic drug pioglitazone (PIO) can improve the phenotype of a mouse Harlequin (Hq) subgroup, presumably due to an ...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2010
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2010.88